Drug-induced liver injury (DILI) is an umbrella term that covers liver injuries developed from diverse mechanisms. The models developed in ToxSTAR cover four liver diseases, namely cholestasis, cirrhosis, hepatitis, and steatosis, which were selected because they were most frequently reported in the post market phase. As DILI is occurred due to reactive metabolites in many cases, additional models to predict toxicity of drug metabolite structures were developed for the four liver diseases.

Below is the summary of model prediction accuracy.